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Crosstalk between Hippo signalling and miRNAs in tumour progression
Author(s) -
Li Nianshuang,
Xie Chuan,
Lu ghua
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13985
Subject(s) - crosstalk , microrna , signalling , hippo signaling pathway , microbiology and biotechnology , signalling pathways , biology , cancer research , computational biology , bioinformatics , signal transduction , genetics , engineering , electronic engineering , gene
The Hippo signalling pathway co‐ordinately modulates cell regeneration and organ size, and its deregulation contributes to tumorigenesis through many cellular processes, including overproliferation, apoptosis resistance and cell migration. Recent discoveries have shed new light on how microRNAs (miRNAs) are closely linked to the Hippo pathway in tumour progression. Hippo signalling has been reported to affect widespread miRNA biogenesis. In turn, several miRNAs regulate Hippo signalling, which contributes to carcinogenesis. This article will provide an overview of the crosstalk between Hippo signalling and miRNAs in the development of cancer and further appraise potential targets for therapeutic intervention.