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Mechanistic roles of autophagy in hematopoietic differentiation
Author(s) -
Riffelmacher Thomas,
Simon AnnaKatharina
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13962
Subject(s) - autophagy , microbiology and biotechnology , haematopoiesis , progenitor cell , biology , stem cell , cellular differentiation , hematopoietic stem cell , apoptosis , genetics , gene
Autophagy is increasingly recognized for its active role in development and differentiation. In particular, its role in the differentiation of hematopoietic cells has been extensively studied, likely because blood cells are accessible, easy to identify and purify, and their progenitor tree is well defined. This review aims to discuss the mechanisms by which autophagy impacts on differentiation, using hematopoietic cell types as examples. Autophagy's roles include the remodeling during terminal differentiation, the maintenance of a long‐lived cell type, and the regulation of the balance between self‐renewal and quiescence in stem‐like cells. We discuss and compare the mechanistic roles of autophagy, such as prevention of apoptosis, supply of energy metabolites and metabolic adaption, and selective degradation of organelles and of regulatory factors.

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