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Not just for coding: a new role for histone tails in replication enzyme activation
Author(s) -
Bielinsky AnjaKatrin,
Leung Wendy
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13958
Subject(s) - okazaki fragments , histone , nucleosome , dna replication , microbiology and biotechnology , endonuclease , histone code , dna , histone h2a , biology , chemistry , biochemistry , eukaryotic dna replication
The processing of Okazaki fragments when they are assembled into nucleosomes has received little attention. In this issue of The FEBS Journal , Seo and colleagues show that binding to histone tails stimulates the enzymatic activity of flap endonuclease 1 (Rad27). Histone tails are structurally similar to the C terminus of Rad27 and can thus mimic its autostimulatory function. This study highlights an active regulatory role for nucleosomes on DNA metabolism.