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Escorted by chaperones: Sti1 helps to usher precursor proteins from the ribosome to mitochondria
Author(s) -
Hansen Katja G.,
Schlagowski Anna,
Herrmann Johannes M.
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13821
Subject(s) - cytosol , hsp90 , mitochondrion , microbiology and biotechnology , ribosome , hsp70 , chaperone (clinical) , biology , biochemistry , heat shock protein , rna , enzyme , gene , medicine , pathology
Little is known about factors that interact with mitochondrial precursor proteins in the cytosol. Employing site‐specific crosslinking this study identifies chaperones of the Hsp70 and Hsp90 families as well as Sti1 as escorts of cytosolic preproteins. Sti1 presumably helps to hand‐over preproteins from Hsp70 to the Hsp90 system and thereby facilitates their binding to TOM receptors on the mitochondrial surface.