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Long and short (timeframe) of endoplasmic reticulum stress‐induced cell death
Author(s) -
Ryoo Hyung Don
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13755
Subject(s) - endoplasmic reticulum , unfolded protein response , programmed cell death , microbiology and biotechnology , cell , medicine , biology , apoptosis , genetics
A number of age‐dependent degenerative diseases are caused by chronic endoplasmic reticulum ( ER ) stress in vital cells. In many cases, the afflicted cells suffer from ER stress since birth, but the death of irreplaceable cells occurs only late in life. Although our understanding of ER stress‐induced cell death has advanced significantly, most of the known mechanisms involve pathways that signal within hours, and it remains unclear how these pathways regulate cell death that occurs only decades later. Here, I highlight the conceptual issues and suggest ways to make sense of the age‐related effect of ER stress‐induced cell death in degenerative diseases.