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The JAK / STAT pathway in obesity and diabetes
Author(s) -
Gurzov Esteban N.,
Stanley William J.,
Pappas Evan G.,
Thomas Helen E.,
Gough Daniel J.
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13709
Subject(s) - stat , diabetes mellitus , jak stat signaling pathway , medicine , obesity , disease , signal transduction , endocrinology , cancer research , biology , receptor , microbiology and biotechnology , stat3 , tyrosine kinase
Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK / STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK / STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK / STAT pathway in treatment of obesity and diabetes.