The  JAK / STAT  pathway in obesity and diabetes | Zendy

Gurzov Esteban N. | Zendy; Stanley William J. | Zendy; Pappas Evan G. | Zendy; Thomas Helen E. | Zendy; Gough Daniel J. | Zendy

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The JAK / STAT pathway in obesity and diabetes

Author(s) -

Gurzov Esteban N.,

Stanley William J.,

Pappas Evan G.,

Thomas Helen E.,

Gough Daniel J.

Publication year - 2016

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.13709

Subject(s) - stat , jak stat signaling pathway , chemistry , signal transduction , biochemistry , stat3 , tyrosine kinase

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK / STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK / STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK / STAT pathway in treatment of obesity and diabetes.

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