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Regenerative strategies for kidney engineering
Author(s) -
Montserrat Nuria,
Garreta Elena,
Izpisua Belmonte Juan Carlos
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13704
Subject(s) - induced pluripotent stem cell , decellularization , kidney , stem cell , biology , microbiology and biotechnology , regeneration (biology) , renal stem cell , homeostasis , regenerative medicine , embryonic stem cell , endocrinology , progenitor cell , extracellular matrix , biochemistry , gene
The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an immune regulator and modulator of cardiovascular physiology. The development of in vitro renal disease models with pluripotent stem cells (both human embryonic stem cells and induced pluripotent stem cells) and the generation of robust protocols for in vitro derivation of renal‐specific‐like cells from patient induced pluripotent stem cells have just emerged. Here we review major findings in the field of kidney regeneration with a major focus on the development of stepwise protocols for kidney cell production from human pluripotent stem cells and the latest advances in kidney bioengineering (i.e. decellularized kidney scaffolds and bioprinting). The possibility of generating renal‐like three‐dimensional structures to be recellularized with renal‐derived induced pluripotent stem cells may offer new avenues to develop functional kidney grafts on‐demand.