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Pulmonary resident neutrophils regulate the production of GM ‐ CSF and alveolar macrophages
Author(s) -
Tian Feng,
Han Yong,
Song Jian,
Lei Jie,
Yan Xiaolong,
Xie Nianlin,
Wang Jian,
Zhao Jinbo,
Liang Xiaohua,
Zhong Daixing,
Zhou Yongan,
Wang Xiaoping,
Li Xiaofei
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13684
Subject(s) - granulopoiesis , alveolar macrophage , microbiology and biotechnology , granulocyte macrophage colony stimulating factor , macrophage , immunology , cd18 , granulocyte , secretion , chemistry , biology , cytokine , flow cytometry , in vitro , haematopoiesis , integrin alpha m , stem cell , biochemistry
Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/ IL ‐23/granulocyte/macrophage colony‐stimulating factor ( GM ‐ CSF ) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD 18‐deficient ( CD 18 −/− ) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL ‐23‐ and GM ‐ CSF ‐dependent manner. The apoptotic neutrophils could inhibit the secretion of IL ‐23 from alveolar macrophages, which is important for the production of GM ‐ CSF , and depletion of neutrophils disrupted the regulation of IL ‐23 and GM ‐ CSF . This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system.