Premium
Effects of aneuploidy on gene expression: implications for cancer
Author(s) -
Dürrbaum Milena,
Storchová Zuzana
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13591
Subject(s) - aneuploidy , biology , transcriptome , gene , genetics , chromosome , genome , phenotype , gene expression , gene dosage , chromothripsis , ploidy , karyotype , genome instability , dna , dna damage
Unbalanced chromosome content, so‐called aneuploidy, is a hallmark of cancer cells. Changes in the copy numbers of chromosomes or large chromosomal regions significantly alter the expression of several hundreds of genes that are gained or lost. At the same time, aneuploidy per se affects the transcription of many genes throughout the entire genome, as several pathways are activated or inhibited in response to changes in chromosome copy number. In recent years, a large amount of quantitative genome, transcriptome and proteome data has enabled comparison of the changes in gene expression observed in aneuploid cancer cells, as well as in model aneuploid cells with defined karyotypes. Here, we summarize how aneuploidy shapes gene expression and how it may contribute to the phenotypes of cancer cells.