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Structures of the double‐ring AAA ATPase Pex1–Pex6 involved in peroxisome biogenesis
Author(s) -
Tan Dongyan,
Blok Neil B.,
Rapoport Tom A.,
Walz Thomas
Publication year - 2016
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13569
Subject(s) - aaa proteins , biogenesis , peroxisome , atpase , biology , microbiology and biotechnology , biochemistry , enzyme , receptor , gene
The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo‐electron microscopy structures of the Pex1–Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.