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p62/ SQSTM 1 functions as a signaling hub and an autophagy adaptor
Author(s) -
Katsuragi Yoshinori,
Ichimura Yoshinobu,
Komatsu Masaaki
Publication year - 2015
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13540
Subject(s) - autophagy , signal transducing adaptor protein , microbiology and biotechnology , keap1 , signal transduction , biology , chemistry , biochemistry , transcription factor , gene , apoptosis
p62/ SQSTM 1 is a stress‐inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/ SQSTM 1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. In addition, p62/ SQSTM 1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates. In the present review, we describe the current knowledge about p62 with regard to mammalian target of rapamycin complex 1 activation, the Keap1–Nrf2 pathway and selective autophagy.