p62/ SQSTM 1 functions as a signaling hub and an autophagy adaptor | Zendy

Katsuragi Yoshinori | Zendy; Ichimura Yoshinobu | Zendy; Komatsu Masaaki | Zendy

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p62/ SQSTM 1 functions as a signaling hub and an autophagy adaptor

Author(s) -

Katsuragi Yoshinori,

Ichimura Yoshinobu,

Komatsu Masaaki

Publication year - 2015

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.13540

Subject(s) - signal transducing adaptor protein , autophagy , microbiology and biotechnology , chemistry , signal transduction , biology , biochemistry , apoptosis

p62/ SQSTM 1 is a stress‐inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/ SQSTM 1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. In addition, p62/ SQSTM 1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates. In the present review, we describe the current knowledge about p62 with regard to mammalian target of rapamycin complex 1 activation, the Keap1–Nrf2 pathway and selective autophagy.

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