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VHR / DUSP 3 phosphatase: structure, function and regulation
Author(s) -
Pavic Karolina,
Duan Guangyou,
Köhn Maja
Publication year - 2015
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13263
Subject(s) - dual specificity phosphatase , phosphatase , protein tyrosine phosphatase , function (biology) , microbiology and biotechnology , phosphorylation , biology , protein phosphatase 2 , mapk/erk pathway , ptpn11 , signal transduction , biochemistry , gene , mutation , kras
Vaccinia H1‐related ( VHR ) phosphatase, also known as dual‐specificity phosphatase ( DUSP ) 3, is a small member of the DUSP (also called DSP ) family of phosphatases. VHR has a preference for phospho‐tyrosine substrates, and has important roles in cellular signaling ranging from cell‐cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR / DUSP 3 has been implicated in several human cancers, where its tumor‐suppressing and ‐promoting properties have been described. We give a detailed overview of VHR / DUSP 3 phosphatase and compare it with its most closely related phosphatases DUSP 13B, DUSP 26 and DUSP 27.