Premium
Programmed necrosis and necroptosis signalling
Author(s) -
Feoktistova Maria,
Leverkus Martin
Publication year - 2015
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13120
Subject(s) - necroptosis , microbiology and biotechnology , signalling , programmed cell death , kinase , biology , protein kinase a , ripk1 , signal transduction , intracellular , apoptosis , biochemistry
In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor‐interacting serine/threonine protein kinase1 ( RIPK 1), RIPK 3, and mixed‐lineage kinase domain‐like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK 1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.