Premium
A short peptide from frog skin accelerates diabetic wound healing
Author(s) -
Liu Han,
Duan Zilei,
Tang Jing,
Lv Qiumin,
Rong Mingqiang,
Lai Ren
Publication year - 2014
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12968
Subject(s) - wound healing , angiogenesis , medicine , diabetes mellitus , pharmacology , wound closure , surgery , cancer research , endocrinology
Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound‐healing ability and represent a resource for prospective wound‐healing promoting compounds. A potential wound‐healing promoting peptide ( CW 49; amino acid sequence APFRMGICTTN ) was identified from the frog skin of Odorrana grahami . It promotes wound healing in a murine model with a full‐thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW 49 also showed a significant anti‐inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW 49 had little effect on re‐epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW 49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW 49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.