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Weak protein complexes: challenging to study but essential for life
Author(s) -
Qin Jun,
Gronenborn Angela M.
Publication year - 2014
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12744
Subject(s) - current (fluid) , transient (computer programming) , computer science , nanotechnology , computational biology , biochemical engineering , data science , biology , physics , engineering , materials science , thermodynamics , operating system
The biological importance of transient or weak protein interactions is only beginning to be appreciated. One limitation to generating a thorough understanding of their underlying nature is the difficulty of applying current biophysical and structural methods in their study. In this issue, several minireviews evaluate current and future possibilities for applying targeted biophysical techniques to investigate weak, transient protein‐ligand complexes.