Premium
miR‐17 regulates the proliferation and differentiation of the neural precursor cells during mouse corticogenesis
Author(s) -
Mao Susu,
Li Hanqin,
Sun Qi,
Zen Ke,
Zhang ChenYu,
Li Liang
Publication year - 2014
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12680
Subject(s) - corticogenesis , biology , bone morphogenetic protein , microbiology and biotechnology , rna , cell growth , cellular differentiation , bone morphogenetic protein receptor , neural stem cell , gene expression , gene , stem cell , genetics , progenitor cell
Micro RNA s (mi RNA s) are endogenously expressed small, non‐coding nucleotides that repress gene expression at the post‐transcriptional level. In mammals, the developing brain contains a large, diverse group of mi RNA s, which suggests that they play crucial roles in neural development. In the present study, we analyzed the mi RNA expression patterns in the mouse cortex at various developmental stages. We found that miR‐17 family mi RNA s were highly expressed in the cortex during early developmental stages, and that their expression levels gradually decreased as the cortex developed. Further investigation revealed that the change in miR‐17‐5p expression occurred in the ventricular zone/sub‐ventricular zone. In addition to promoting cell proliferation, miR‐17‐5p also influences the differentiation fate of neural precursor cells exposed to bone morphogenetic protein 2. Moreover, we show that these effects of miR‐17‐5p were mainly the result of regulating the bone morphogenetic protein signaling pathway by repressing expression of the bone morphogenetic protein type II receptor. Taken together, these findings suggest that miR‐17 family members play a pivotal role in regulating cell activity during early development of the mouse cortex.