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Retracted: Micro RNA ‐183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP 6
Author(s) -
Wang Jianwen,
Wang Xiaochun,
Li Zhongji,
Liu Hongtao,
Teng Yan
Publication year - 2014
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12659
Subject(s) - retinoblastoma , downregulation and upregulation , microrna , cell growth , lrp6 , microbiology and biotechnology , chemistry , wnt signaling pathway , ectopic expression , viability assay , cell migration , cell , cell culture , biology , signal transduction , gene , biochemistry , genetics
Our study demonstrates the downregulation of micro RNA ‐183 (mi R ‐183) in retinoblastoma ( RB ) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of mi R ‐183 in the RB cell lines Y 79, SO ‐ RB 50 and WERI ‐ RB 1 suppresses cell viability, migration and invasion. Furthermore, the W nt co‐receptor low‐density lipoprotein receptor‐related protein 6 ( LRP 6) was identified as a new target of mi R ‐183, and restoration of the expression of LRP 6 rescues the effects induced by mi R ‐183 in RB cells. These results indicate that miR‐183 targets and downregulates LRP 6 in the growth, migration and invasion of RB cells.