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The proto‐oncogene JUN is a target of the heat shock transcription factor HSF 1
Author(s) -
Sawai Maki,
Ishikawa Yukio,
Ota Azumi,
Sakurai Hiroshi
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12570
Subject(s) - hsf1 , heat shock factor , transcription factor , heat shock , microbiology and biotechnology , biology , activator (genetics) , heat shock protein , c jun , promoter , transcription (linguistics) , hspa12a , gene expression , gene , hsp70 , genetics , linguistics , philosophy
The transcription factor activator protein‐1 ( AP ‐1) participates in many aspects of cell physiology, such as cellular proliferation, transformation, and death. AP ‐1 is a dimeric complex that primarily contains Jun and Fos family members. Here, we report that JUN is a target of heat shock transcription factor HSF 1. HSF 1 is the master regulator of genes encoding molecular chaperones, and is involved in cellular processes such as the stress response, cell differentiation, aging and carcinogenesis. In H e L a cells, JUN transcription was rapidly induced by heat treatment. We found that HSF 1 bound to the JUN promoter and was necessary for its efficient response to heat shock. In heat‐shocked cells, c‐Jun‐mediated gene expression was induced slowly following accumulation of c‐Jun protein. Forced expression of active HSF 1 in cells resulted in an increase in c‐Jun expression and activation of c‐Jun target genes. These results show that HSF 1 regulates JUN expression, thereby modulating AP ‐1 activity.