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Calcium oscillations triggered by cardiotonic steroids
Author(s) -
Fontana Jacopo M.,
Burlaka Ievgeniia,
Khodus Georgiy,
Brismar Hjalmar,
Aperia Anita
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12448
Subject(s) - inositol , calcium , chemistry , signal (programming language) , receptor , endocrinology , signal transduction , medicine , microbiology and biotechnology , biophysics , biology , biochemistry , computer science , programming language
Na + , K + –ATPase ( NKA ) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca 2+ oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca 2+ signal activates the NF‐κB subunit p65 and increases the expression of the antiapoptotic factor Bcl‐xL. The potential tissue‐protective effects of this signal are discussed.