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Sphingosine‐1‐phosphate receptor 2
Author(s) -
Adada Mohamad,
Canals Daniel,
Hannun Yusuf A.,
Obeid Lina M.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12446
Subject(s) - sphingosine 1 phosphate , sphingosine 1 phosphate receptor , sphingosine , receptor , angiogenesis , microbiology and biotechnology , s1pr1 , biology , g protein coupled receptor , sphingolipid , immune system , inflammation , signal transduction , cancer research , immunology , biochemistry , vascular endothelial growth factor a , vascular endothelial growth factor , vegf receptors
Sphingosine‐1‐phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein‐coupled receptors, specifically five S1P receptors (S1 PR s). The identified S1 PR s differ in cellular and tissue distribution, and each is coupled to specific G proteins, which mediate unique functions. Here, we describe functional characteristics of all five receptors, emphasizing S1 PR 2, which is critical in the immune, nervous, metabolic, cardiovascular, musculoskeletal, and renal systems. This review also describes the role of this receptor in tumor growth and metastasis and suggests potential therapeutic avenues that exploit S1 PR 2.