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Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity
Author(s) -
Thrush A. Brianne,
Dent Robert,
McPherson Ruth,
Harper MaryEllen
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12399
Subject(s) - weight loss , obesity , energy expenditure , energy metabolism , skeletal muscle , uncoupling protein , function (biology) , endocrinology , biology , medicine , microbiology and biotechnology , brown adipose tissue
Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity‐related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.