Engineered proteins with  P umilio/ fem‐3  m RNA  binding factor scaffold to manipulate  RNA  metabolism | Zendy

Wang Yang | Zendy; Wang Zefeng | Zendy; Tanaka Hall Traci M. | Zendy

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Engineered proteins with P umilio/ fem‐3 m RNA binding factor scaffold to manipulate RNA metabolism

Author(s) -

Wang Yang,

Wang Zefeng,

Tanaka Hall Traci M.

Publication year - 2013

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.12367

Subject(s) - rna , rna binding protein , messenger rna , sequence (biology) , computational biology , microbiology and biotechnology , chemistry , biology , biochemistry , gene

Pumilio/ fem‐3 m RNA binding factor proteins are characterized by a sequence‐specific RNA ‐binding domain. This unique single‐stranded RNA recognition module, whose sequence specificity can be reprogrammed, has been fused with functional modules to engineer protein factors with various functions. We summarize the advances made with respect to developing RNA regulatory tools, as well as opportunities for the future.

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