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Engineered proteins with P umilio/ fem‐3 m RNA binding factor scaffold to manipulate RNA metabolism
Author(s) -
Wang Yang,
Wang Zefeng,
Tanaka Hall Traci M.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12367
Subject(s) - rna , rna binding protein , microbiology and biotechnology , sequence (biology) , computational biology , biology , biochemistry , gene
Pumilio/ fem‐3 m RNA binding factor proteins are characterized by a sequence‐specific RNA ‐binding domain. This unique single‐stranded RNA recognition module, whose sequence specificity can be reprogrammed, has been fused with functional modules to engineer protein factors with various functions. We summarize the advances made with respect to developing RNA regulatory tools, as well as opportunities for the future.