In the eye of the storm: mitochondrial damage during heart and brain ischaemia | Zendy

Borutaite Vilmante | Zendy; Toleikis Adolfas | Zendy; Brown Guy C. | Zendy

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In the eye of the storm: mitochondrial damage during heart and brain ischaemia

Author(s) -

Borutaite Vilmante,

Toleikis Adolfas,

Brown Guy C.

Publication year - 2013

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.12353

Subject(s) - cytochrome c oxidase , mitochondrial permeability transition pore , ischemia , mitochondrion , cytochrome c , nitric oxide , chemistry , cytochrome , mitochondrial apoptosis induced channel , pharmacology , biochemistry , biology , medicine , apoptosis , enzyme , programmed cell death , endocrinology

We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia‐induced and/or reperfusion‐induced: (a) inhibition of mitochondrial respiratory complex I; (b) release of cytochrome c from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complex I, release of cytochrome c , and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexes I and IV , but other effects are less clear.

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