Premium
In the eye of the storm: mitochondrial damage during heart and brain ischaemia
Author(s) -
Borutaite Vilmante,
Toleikis Adolfas,
Brown Guy C.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12353
Subject(s) - cytochrome c oxidase , mitochondrial permeability transition pore , ischemia , mitochondrion , cytochrome c , nitric oxide , chemistry , cytochrome , mitochondrial apoptosis induced channel , pharmacology , biochemistry , biology , medicine , apoptosis , enzyme , programmed cell death , endocrinology
We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia‐induced and/or reperfusion‐induced: (a) inhibition of mitochondrial respiratory complex I; (b) release of cytochrome c from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complex I, release of cytochrome c , and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexes I and IV , but other effects are less clear.