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Post‐translational modifications of CFTR : insight into protein trafficking and cystic fibrosis disease
Author(s) -
Amaral Margarida D.,
Farinha Carlos M.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12345
Subject(s) - cystic fibrosis , biogenesis , phosphorylation , microbiology and biotechnology , cystic fibrosis transmembrane conductance regulator , signal transduction , disease , posttranslational modification , biology , medicine , computational biology , chemistry , pathology , biochemistry , genetics , enzyme , gene
CFTR , which when mutated causes C ystic F ibrosis, constitutes an excellent model of regulated traffic of plasma membrane proteins. This M ini‐ R eviews S eries covers major aspects by which post‐translational modifications regulate CFTR biogenesis and trafficking, giving new insights into well‐established mechanisms and covering novel aspects (such as the role of phosphorylation in the regulation of membrane stability or the relevance of signalling pathways in CF disease).