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Expanding functions of intracellular resident mono‐ ADP ‐ribosylation in cell physiology
Author(s) -
Feijs Karla L. H.,
Verheugd Patricia,
Lüscher Bernhard
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12315
Subject(s) - adp ribosylation , poly adp ribose polymerase , dna damage , wnt signaling pathway , dna repair , microbiology and biotechnology , chemistry , intracellular , dna , biology , biochemistry , signal transduction , enzyme , polymerase , nad+ kinase
Poly‐ ADP ‐ribosylation functions in diverse signaling pathways, such as Wnt signaling and DNA damage repair, where its role is relatively well characterized. Contrarily, mono‐ ADP ‐ribosylation by for example ARTD 10/ PARP 10 is much less understood. Recent developments hint at the involvement of mono‐ ADP ‐ribosylation in transcriptional regulation, the unfolded protein response, DNA repair, insulin secretion and immunity. Additionally, macrodomain‐containing hydrolases, MacroD1, MacroD2 and C6orf130/ TARG 1, have been identified that make mono‐ ADP ‐ribosylation reversible. Complicating further progress is the lack of tools such as mono‐ ADP ‐ribose‐specific antibodies. The currently known functions of mono‐ ADP ‐ribosylation are summarized here, as well as the available tools such as mass spectrometry to study this modification in vitro and in cells.