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What do we know about the transient receptor potential vanilloid 2 ( TRPV 2) ion channel?
Author(s) -
PerálvarezMarín Alex,
DoñateMacian Pau,
Gaudet Rachelle
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12302
Subject(s) - transient receptor potential channel , trpv , trpv1 , chemistry , ion channel , trpc5 , trpv4 , subfamily , biophysics , receptor , trpc1 , microbiology and biotechnology , neuroscience , biochemistry , biology , gene
Transient receptor potential ( TRP ) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily ( TRPV ) named after the vanilloid receptor 1 ( TRPV 1) consists of six members, and at least four of them ( TRPV 1– TRPV 4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV 2. Although initially characterized as a noxious heat sensor, TRPV 2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV 2 in an attempt to shed some light on the physiological and pharmacological deorphanization of TRPV 2.