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Recent progress in satellite cell/myoblast engraftment – relevance for therapy
Author(s) -
Briggs Deborah,
Morgan Jennifer E.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12273
Subject(s) - cell therapy , satellite , dystrophin , transplantation , stem cell therapy , stem cell , medicine , muscular dystrophy , biology , microbiology and biotechnology , engineering , aerospace engineering
There is currently no cure for muscular dystrophies, although several promising strategies are in basic and clinical research. One such strategy is cell transplantation with satellite cells (or their myoblast progeny) to repair damaged muscle and provide dystrophin protein with the aim of preventing subsequent myofibre degeneration and repopulating the stem cell niche for future use. The present review aims to cover recent advances in satellite cell/myoblast therapy and to discuss the challenges that remain for it to become a realistic therapy.