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On the future of mass‐spectrometry‐based lipidomics
Author(s) -
LoizidesMangold Ursula
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12202
Subject(s) - lipidomics , organelle , lipidome , lipid signaling , membrane lipids , computational biology , chemistry , lipid metabolism , mass spectrometry , biology , microbiology and biotechnology , biochemistry , membrane , chromatography , receptor
Lipids have highly diverse functions that go beyond cellular membrane structure and energy storage. One of the great challenges in lipid research will be to understand how the enormous complexity of lipid homeostasis is maintained. Genetic approaches combined with mass spectrometry ‐based lipidomics will help to elucidate how cells create and maintain their nonrandom lipid distribution within tissues, cells, organelles and lipid bilayers. Lipid homeostasis is crucial for many cellular processes and we are currently only beginning to understand the specific functions of lipids and the local environment that they create.