Premium
Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration
Author(s) -
Saclier Marielle,
Cuvellier Sylvain,
Magnan Mélanie,
Mounier Rémi,
Chazaud Bénédicte
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12166
Subject(s) - myogenesis , skeletal muscle , regeneration (biology) , macrophage , microbiology and biotechnology , phagocytosis , monocyte , myocyte , biology , immunology , chemistry , anatomy , in vitro , biochemistry
Adult skeletal muscle has the remarkable property of regenerating after damage, owing to satellite cells and myogenic precursor cells becoming committed to adult myogenesis to rebuild the muscle. This process is accompanied by the continuing presence of macrophages, from the phagocytosis of damaged myofibres to the full re‐formation of new myofibres. In recent years, there has been huge progress in our understanding of the roles of macrophages during skeletal muscle regeneration, notably concerning their effects on myogenic precursor cells. Here, we review the most recent knowledge acquired on monocyte entry into damaged muscle, the various macrophage subpopulations, and their respective roles during the sequential phases of muscle repair. We also discuss the role of macrophages after exercise‐induced muscle damage, notably in humans.