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Heavy metal‐associated isoprenylated plant protein ( HIPP ): characterization of a family of proteins exclusive to plants
Author(s) -
AbreuNeto João Braga,
TurchettoZolet Andreia C.,
Oliveira Luiz Felipe Valter,
Bodanese Zanettini Maria Helena,
MargisPinheiro Marcia
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12159
Subject(s) - cytosol , microbiology and biotechnology , gene , biology , prenylation , botany , chemistry , biochemistry , enzyme
Metallochaperones are key proteins for the safe transport of metallic ions inside the cell. HIPP s (heavy metal‐associated isoprenylated plant proteins) are metallochaperones that contain a metal binding domain ( HMA ) and a C –terminal isoprenylation motif. In this study, we provide evidence that proteins of this family are found only in vascular plants and may be separated into five distinct clusters. HIPP s may be involved in (a) heavy metal homeostasis and detoxification mechanisms, especially those involved in cadmium tolerance, (b) transcriptional responses to cold and drought, and (c) plant–pathogen interactions. In particular, our results show that the rice ( O ryza sativa ) HIPP O s HIPP 41 gene is highly expressed in response to cold and drought stresses, and its product is localized in the cytosol and the nucleus. The results suggest that HIPP s play an important role in the development of vascular plants and in plant responses to environmental changes.