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The regulatory roles of small leucine‐rich proteoglycans in extracellular matrix assembly
Author(s) -
Chen Shoujun,
Birk David E.
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12136
Subject(s) - extracellular matrix , microbiology and biotechnology , extracellular , decorin , function (biology) , biology , matrix (chemical analysis) , proteoglycan , chemistry , chromatography
Small leucine‐rich proteoglycans ( SLRP s) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly. SLRP s have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of SLRP s with other molecules result in tissue‐specific spatial and temporal distributions. The changing expression patterns play a critical role in the regulation of tissue‐specific matrix assembly and therefore tissue function. SLRP s play significant structural roles within extracellular matrices. In addition, they play regulatory roles in collagen fibril growth, fibril organization and extracellular matrix assembly. Moreover, they are involved in mediating cell–matrix interactions. Abnormal SLRP expression and/or structures result in dysfunctional extracellular matrices and pathophysiology. Altered expression of SLRP s has been found in many disease models, and structural deficiency also causes altered matrix assembly. SLRP s regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function.