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Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes
Author(s) -
Li Yingxiu,
Shin Donghee,
Kwon So Hee
Publication year - 2013
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.12079
Subject(s) - hdac6 , histone deacetylase , hdac10 , biology , histone , regulator , function (biology) , computational biology , microbiology and biotechnology , biochemistry , gene
Histone deacetylase ( HDAC ) 6 is the best‐characterized class II b deacetylase that regulates many important biological processes via the formation of complexes with its partner proteins. HDAC 6 is important both for cytoplasmic and nuclear functions. Unlike other deacetylases, HDAC 6 has unique substrate specificity for nonhistone proteins. Such diverse functions of HDAC 6 suggest that it serves a potential therapeutic target for the treatment of a wide range of diseases. This therapeutic interest in HDAC 6 stems from the observation that HDAC 6 may be overexpressed or deregulated in various cancers, neurodegenerative diseases and inflammatory disorders. Despite extensive efforts, however, very few HDAC 6‐selective inhibitors have been identified and the precise structural determinants remain undefined. Future efforts aiming to better define the structure and function of HDAC 6 should provide the basis for the discovery of novel effective inhibitors. In this review, we focus on recent studies that highlight the importance of HDAC 6‐mediated biological processes, disease mechanisms and HDAC 6‐selective inhibitors.