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Centrally acting antihypertensives change the psychogenic cardiovascular reactivity
Author(s) -
Mendonça Michelle M.,
Costa Amanda N.,
Moraes Gean C.A.,
Martins Gustavo M.,
Almeida Aline F.,
Rincon Gabriel C.N.,
Siqueira João P.R.,
Padilha Daniella M.,
Moya Marcela I.,
FerreiraNeto Marcos L.,
Gomes Rodrigo Mello,
Pedrino Gustavo Rodrigues,
Fontes Marco Antônio Peliky,
Colombari Eduardo,
Crestani Carlos C.,
Fajemiroye James O.,
Xavier Carlos Henrique
Publication year - 2021
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12648
Subject(s) - heart rate , blood pressure , medicine , tachycardia , endocrinology , clonidine , microneurography , anesthesia , chemistry , baroreflex
Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control ‐ CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air‐jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air‐jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air‐jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air‐jet‐induced tachycardia.