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Antidepressant‐like effect of low dose of scopolamine in the H/Rouen genetic mouse model of depression
Author(s) -
El Yacoubi Malika,
Vaugeois JeanMarie,
Jamain Stéphane
Publication year - 2021
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12639
Subject(s) - antidepressant , nbqx , pharmacology , antagonist , behavioural despair test , muscarinic antagonist , muscarinic acetylcholine receptor , ampa receptor , anticholinergic , tail suspension test , chemistry , medicine , endocrinology , receptor , hippocampus , nmda receptor
Rodent models of depression are useful for the investigation of cellular and neuronal mechanisms of antidepressant drugs and for the discovery of potential new targets. In this study, we examined the antidepressant‐like effect of scopolamine, a non‐selective muscarinic antagonist, in a genetic mouse model of depression obtained through a selective breeding strategy and called H/Rouen. In this model, we observed that scopolamine was active both in males and females at a lower dose (0.03 mg/kg) in the tail suspension test, 30 min following its administration, than observed in CD‐1 mice. In addition, we showed this antidepressant‐like effect was partly inhibited by an injection of 10 mg/kg of the AMPA receptor antagonist NBQX in both males and females, suggesting the antidepressant‐like effect of scopolamine was mainly driven by AMPA receptors in the H/Rouen mouse line. Altogether, our results showed the high sensitivity of the H/Rouen mouse model of depression to study the antidepressant‐like effects of pharmacological compounds.