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Antibiotics with therapeutic effects on spinal cord injury: a review
Author(s) -
Afshari Khashayar,
Momeni Roudsari Nazanin,
Lashgari NaserAldin,
Haddadi NazgolSadat,
HajMirzaian Arvin,
Hassan Nejad Malihe,
Shafaroodi Hamed,
Ghasemi Mehdi,
Dehpour Ahmad Reza,
Abdolghaffari Amir Hossein
Publication year - 2021
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12605
Subject(s) - minocycline , antibiotics , medicine , neuroprotection , spinal cord injury , spinal cord , central nervous system , pharmacology , therapeutic effect , biology , psychiatry , microbiology and biotechnology
Accumulating evidence indicates that a considerable number of antibiotics exert anti‐inflammatory and neuroprotective effects in different central and peripheral nervous system diseases including spinal cord injury (SCI). Both clinical and preclinical studies on SCI have found therapeutic effects of antibiotics from different families on SCI. These include macrolides, minocycline, β‐lactams, and dapsone, all of which have been found to improve SCI sequels and complications. These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI‐related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.