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Cancer stem cells as therapeutic targets of pancreatic cancer
Author(s) -
Razi Ebrahim,
Radak Mehran,
Mahjoubin-Tehran Maryam,
Talebi Samaneh,
Shafiee Alimohammad,
Hajighadimi Sarah,
Moradizarmehri Sanaz,
Sharifi Hossein,
Mousavi Nousin,
Sarvizadeh Mostafa,
Nejati Majid,
Taghizadeh Mohsen,
Ghasemi Faezeh
Publication year - 2020
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12521
Subject(s) - cancer stem cell , pancreatic cancer , context (archaeology) , stem cell , cancer research , metastasis , cancer , cancer cell , population , biology , tumor initiation , immunology , medicine , microbiology and biotechnology , genetics , paleontology , environmental health
The discovery of stem cells and their potential abilities in self‐renewal and differentiation has opened a new horizon in medicine. Scientists have found a small population of stem cells in some types of cancers with the same functions as normal stem cells. There are two models for tumor progression: clonal (stochastic) and cancer stem cell (CSCs) models. According to the first model, all transformed cells in the tumor have carcinogenic potential and are able to proliferate and produce the same cells. The latter model, which has received more attention recently, considers the role of CSCs in drug resistance and tumor metastasis. Following the model, researchers have found that targeting CSCs may be a promising way in cancer therapy. This review describes CSC characteristics in general, while also focusing on CSC properties in the context of pancreatic cancer.