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Efficacy and safety of subcutaneous administration of ceftazidime as a salvage therapy in geriatrics: a case report
Author(s) -
Michelon Hugues,
Tardivel Marie,
Dinh Aurélien,
Alvarez JeanClaude,
Salomon Elsa,
Le Quintrec JeanLaurent,
Hirt Deborah,
Davido Benjamin
Publication year - 2020
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12520
Subject(s) - ceftazidime , medicine , cephalosporin , antibiotics , route of administration , salvage therapy , cephalosporin antibiotic , intramuscular injection , intensive care medicine , surgery , pseudomonas aeruginosa , anesthesia , chemotherapy , bacteria , microbiology and biotechnology , genetics , biology
Ceftazidime is a third‐generation cephalosporin used for the treatment of Gram‐negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off‐label subcutaneous injection could be a salvage route for the administration of antibiotics, especially in geriatrics, despite the paucity of evidence about efficacy and safety. We report a case of a successful and well‐tolerated subcutaneous ceftazidime therapy in a 90‐year‐old woman for the treatment of an acute urinary tract infection caused by Pseudomonas aeruginosa with therapeutic drug monitoring data.