English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

To date, no reports of hypersensitivity reactions ( HSR s) among nonsteroidal anti‐inflammatory drugs ( NSAID s) according to cyclo‐oxygenase ( COX ) selectivity and chemical groups have been published in a single study. The present study assessed the reporting frequency of  HSR s for  NSAID s based on their relative inhibitory potency toward  COX  enzymes and chemical groups, including the presence/absence of a functional sulfonamide group, in strata observed 5 years after market authorization. A case/noncase study was performed among individual case safety reports ( ICSR s) with  NSAID s as suspected drugs in VigiBase, the  WHO  spontaneous reporting database. Cases were  ICSR s mentioning angioedema and anaphylactic/anaphylactoid shock conditions, while noncases were  ICSR s without  HSR s.  NSAID s were categorized into (i)  NSAID s with high  COX ‐2 selectivity (coxibs), (ii) noncoxib  NSAID s with  COX ‐2 preference, (iii)  NSAID s with poor selectivity, or (iv)  NSAID s with unknown selectivity. Chemical groups were defined based on the Anatomical Therapeutic Chemical classification system and the presence/absence of a functional sulfonamide group. Reporting odds ratios ( ROR s) and 95% confidence intervals (95%  CI s) were calculated using logistic regression analysis. We identified 13 229 cases and 106 444 noncases. In the first 5 years after marketing, poor‐selectivity  NSAID s and acetic acid derivatives were associated with the highest  ROR  of  HSR s (age‐ and sex‐adjusted  ROR  2.12, 95%  CI  1.98–2.28; and  ROR  2.21, 95%  CI  1.83–2.66, respectively) compared with coxibs, and sulfonamide  NSAID s were associated with the highest  ROR  of  HSR s compared with nonsulfonamide  NSAID s (age‐ and sex‐adjusted  ROR  1.38, 95%  CI  1.29–1.47). After the first 5 years of marketing, most of the  ROR s returned to approximately 1.

fundamental and clinical pharmacology

Cyclo‐oxygenase selectivity and chemical groups of nonsteroidal anti‐inflammatory drugs and the frequency of reporting hypersensitivity reactions: a case/noncase study in VigiBase