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Non‐steroidal anti‐inflammatory drug prescriptions from the 6 th month of pregnancy: impact of advice from health authorities
Author(s) -
Araujo Mélanie,
HuraultDelarue Caroline,
Bouilhac Claire,
Petiot Dominique,
Benevent Justine,
Vayssière Christophe,
Vidal Sabine,
Montastruc JeanLouis,
DamaseMichel Christine,
Lacroix Isabelle
Publication year - 2019
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12460
Subject(s) - medicine , medical prescription , pregnancy , ketoprofen , ibuprofen , obstetrics , pharmacology , biology , genetics
Non‐steroidal anti‐inflammatory drugs ( NSAID s) are among the most widely used drugs. On June 2008 and February 2009, Dear Doctor Letters ( DDL s) were sent by the French Health Authorities ( AFSSAPS ) to remind practitioners of risks with NSAID s after the fifth month of pregnancy. The aim of this study was to evaluate the impact of these letters on NSAID prescriptions during late pregnancy. EFEMERIS is a French database that registers drugs prescribed and reimbursed during pregnancy and outcomes between 2004 and 2015. We performed a descriptive study and a ‘before‐and‐after’ comparison of NSAID prescriptions between 3 June 2006 and 3 June 2008 (‘before group’), and between 1 March 2010 and 1 March 2012 (‘after group’). We carried out a Cochran Armitage trend test to check whether the rate of women exposed to NSAID s varies linearly over time. We identified 948 (4.38%) pregnant women in the ‘before group’ and 678 (2.73%) in the ‘after group’ receiving at least one NSAID prescription in late pregnancy ( P < 0.0001). Between 2006 and 2012, mainly prescriptions for morniflumate/niflumic acid (1.7% vs. 0.9%; P < 0.0001), ibuprofen (0.8% vs. 0.6%; P = 0.01) and ketoprofen (0.7% vs. 0.3%; P < 0.0001) fell significantly after DDL s. The Cochran Armitage trend test shows that the percentage of women exposed to NSAID s in late pregnancy decreased significantly during the study period ( P < 0.0001). This study highlighted a significant decrease in the percentage of women receiving NSAID prescriptions during late pregnancy after DDL s. This decrease is not linked to a specific women's profile or prescriber's medical discipline.