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New insights on relaxant effects of (—)‐borneol monoterpene in rat aortic rings
Author(s) -
Santos Stefânia E.,
Ribeiro Fernanda P.R.A.,
Menezes Pedro M.N.,
DuarteFilho Luiz A.M.,
Quintans Jullyana S.S.,
QuintansJunior Lucindo J.,
Silva Fabricio S.,
Ribeiro Luciano A.A.
Publication year - 2019
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12417
Subject(s) - borneol , glibenclamide , chemistry , pharmacology , nitric oxide , monoterpene , biochemistry , medicine , endocrinology , alternative medicine , organic chemistry , pathology , traditional chinese medicine , diabetes mellitus
The monoterpene alcohol (−)‐borneol has many biological effects such as sedative, anti‐inflammatory, analgesic, anti‐nociceptive, antithrombotic and vasorelaxant effects. Our objective in this study was to investigate the mechanism of action of (−)‐borneol and determine its vasorelaxant effect. (−)‐Borneol was tested on isolated aortic rings contracted with PE (10 −6 m ). This study was performed in the absence or in the presence of endothelium, L‐ NAME (100 μ m ), indomethacin (10 μ m ), TEA (1 and 10 m m ), 4‐ AP (1 m m ) or glibenclamide (1 m m ) to assess the participation of EDRF , nitric oxide, prostanoids and potassium channels on the relaxing effect of (−)‐borneol. In this work, (−)‐borneol induced a relaxant effect in aortic rings, with and without endothelium, in a concentration‐dependent manner. The pharmacological characterization obtained using L‐ NAME , indomethacin, TEA , 4‐ AP and glibenclamide demonstrates that the effect of (−)‐borneol was modified in the presence of L‐ NAME , indomethacin and glibenclamide showing that these signal transduction pathways are involved in the relaxing effect of the monoterpene. (−)‐Borneol has a vasorelaxant effect that depends on the presence of vascular endothelium, with the participation of nitric oxide and prostanoids. Also, (−)‐borneol displayed a direct action on the vascular smooth muscle, greatly dependent on K ATP channels.