Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses  hERG  K +  currents expressed in  HEK 293 cells | Zendy

Song Tao | Zendy; Zhang Yuanyuan | Zendy; Song Qiongtao | Zendy; Han Xue | Zendy; Guan Shengjiang | Zendy; Zhang Xuan | Zendy; Chu Xi | Zendy; Zhang Fenghua | Zendy; Zhang Jianping | Zendy; Chu Li | Zendy

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Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K + currents expressed in HEK 293 cells

Author(s) -

Song Tao,

Zhang Yuanyuan,

Song Qiongtao,

Han Xue,

Guan Shengjiang,

Zhang Xuan,

Chu Xi,

Zhang Fenghua,

Zhang Jianping,

Chu Li

Publication year - 2017

Publication title -

fundamental and clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.655

H-Index - 73

eISSN - 1472-8206

pISSN - 0767-3981

DOI - 10.1111/fcp.12306

Subject(s) - bufalin , herg , chemistry , inhibitory postsynaptic potential , channel blocker , ic50 , potassium channel , medicine , endocrinology , pharmacology , in vitro , biology , biochemistry , apoptosis , organic chemistry , calcium

In this study, we investigated the effect of bufalin on the human ether‐à‐go‐go‐related gene ( hERG ) K + channels using the perforated patch recording technique. We measured a half‐maximal inhibitory concentration ( IC 50 ) of 24.83 μ M and maximal inhibitory effect of 39.45 ± 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K + channel blocker and may provide a new way for understanding Chan Su‐induced arrhythmia.

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