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Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K + currents expressed in HEK 293 cells
Author(s) -
Song Tao,
Zhang Yuanyuan,
Song Qiongtao,
Han Xue,
Guan Shengjiang,
Zhang Xuan,
Chu Xi,
Zhang Fenghua,
Zhang Jianping,
Chu Li
Publication year - 2017
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12306
Subject(s) - bufalin , herg , chemistry , inhibitory postsynaptic potential , channel blocker , ic50 , potassium channel , medicine , endocrinology , pharmacology , in vitro , biology , biochemistry , apoptosis , organic chemistry , calcium
In this study, we investigated the effect of bufalin on the human ether‐à‐go‐go‐related gene ( hERG ) K + channels using the perforated patch recording technique. We measured a half‐maximal inhibitory concentration ( IC 50 ) of 24.83 μ M and maximal inhibitory effect of 39.45 ± 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K + channel blocker and may provide a new way for understanding Chan Su‐induced arrhythmia.