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Double‐stranded RNA‐dependent protein kinase signalling and paradigms of cardiometabolic syndrome
Author(s) -
Kalra Jaspreet,
Dhar Arti
Publication year - 2017
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12261
Subject(s) - insulin resistance , metabolic syndrome , inflammation , pathogenesis , oxidative stress , protein kinase a , medicine , kinase , endocrinology , biology , bioinformatics , diabetes mellitus , microbiology and biotechnology
Abstract Metabolic syndrome (Met S) is a collection of the most severe cardiometabolic risk factors that encompasses raised fasting plasma glucose, dyslipidaemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its aetiology. Recently, double‐stranded RNA ‐dependent protein kinase has been found to intersect at the cross‐road of oxidative stress, inflammation and apoptosis in several metabolic diseases. Therefore, an effort has been made in the present review to discuss the role of double‐stranded RNA‐dependent protein kinase and above‐mentioned mechanisms in the progression of Met S, along with its interlinking in major clinical manifestations of Met S such as hypertension and diabetic cardiomyopathy.