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Research review on the pharmacological effects of astragaloside IV
Author(s) -
Li Lei,
Hou Xiaojiao,
Xu Rongfang,
Liu Chang,
Tu Menbayaer
Publication year - 2017
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12232
Subject(s) - medicine , astragalus , pharmacology , signalling pathways , immune system , mechanism (biology) , fibrosis , immunology , traditional chinese medicine , receptor , pathology , philosophy , alternative medicine , epistemology
Astragalus membranaceus Bunge has been used to treat numerous diseases for thousands of years. As the main active substance of Astragalus membranaceus Bunge , astragaloside IV ( AS ‐ IV ) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. Based on studies published during the past several decades, the current state of AS ‐ IV research and the pharmacological effects are detailed, elucidated, and summarized. This review systematically summarizes the pharmacological effects, metabolism mechanism, and the toxicity of AS ‐ IV . AS ‐ IV has multiple pharmacologic effects, including anti‐inflammatory, antifibrotic, antioxidative stress, anti‐asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, AS ‐ IV possesses potential for broad application in many diseases.