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Mania associated with ranitidine: a case report and review of literature
Author(s) -
Mauran Audrey,
Goze Tudi,
Abadie Delphine,
BondonGuitton Emmanuelle,
Chevrel Pauline,
Schmitt Laurent,
Montastruc JeanLouis,
Montastruc François
Publication year - 2016
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12201
Subject(s) - mania , ranitidine , medicine , delirium , confusion , headaches , pediatrics , psychiatry , bipolar disorder , lithium (medication) , psychology , psychoanalysis
H2 receptor antagonists can be associated with central adverse drug reactions ( ADR s), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a ‘serious’ case of severe mania leading to hospitalization in a 42‐year‐old alcohol‐dependent man, 4 days after ranitidine introduction. Review of literature showed that this ‘very rare’ ADR occurs mainly in patients with predisposing factors: age, decrease in renal and/or hepatic function, polymedication, alcohol. Knowledge of this ADR can be particularly important for these drugs widely used as self‐medication.