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Poster Abstracts
Author(s) -
Kasra Azarnoush,
Chouki Chenaf,
Bruno Pereira,
Alexia Lebreton,
Vedat Eljezi,
B. Cosserand,
Damien Bouvier,
Nicolas D’Ostrevy,
M. Zénut,
Lionel Camilleri
Publication year - 2016
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12190
Subject(s) - citation , library science , pharmacovigilance , computer science , medicine , pharmacology , drug
Special Issue: Abstracts of the 20th Annual Meeting of French Society of Pharmacology and Therapeutics, 37th Pharmacovigilance Meeting, 17th APNET Seminar, 14th CHU CIC Meeting, 19–21 April 2016, Nancy, FranceIntroduction: Between September and December 2012, unusual postoperative bleedings occurred in all on-pump cardiac surgery in our heart-surgery department of Clermont- Ferrand University Hospital. This issue was concomitant to the replacement of Choay heparina by Panpharma heparin. The aim of this study isto compare the postoperative hemostasis between these two heparins.Material and methods: We retrospectively compared the operative and postoperative surgical data from patients who had undergone surgery during this 4-month period when Panpharma heparin (group P, 257 patients) was used with data from patients who had undergone surgery during the following 3 months and received Choay (group C, 194 patients).Results: There was no signicant difference between the two groups in terms of preoperative characteristics, operative indications, or theoretical heparin doses.Despite group P receiving a signicantly lower total dose of heparin (mean dose 21 000 IU/CEC) compared to group C (mean dose 22 000 IU/CEC) ( P = 0.05), the number of surgical re-explorations needed to perfect postoperative hemostasis was signicantly higher for group P (3.5% vs. 0) (P = 0.01). Heparin anti-Xa activity after surgery had higher anticoagulant activity in group P at postoperative h1 and h12 compared to group C, which accounted for the greater postoperative surgical re-explorations in group