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Efficacy of nebulized L‐epinephrine for treatment of croup: a randomized, double‐blind study
Author(s) -
Eghbali Aziz,
Sabbagh Ali,
Bagheri Bahador,
Taherahmadi Hassan,
Kahbazi Manijeh
Publication year - 2016
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12158
Subject(s) - croup , medicine , epinephrine , dexamethasone , anesthesia , randomized controlled trial , heart rate , placebo , saline , blood pressure , surgery , pediatrics , alternative medicine , pathology
The objective of this study was to compare the effect of L‐epinephrine plus dexamethasone vs. dexamethasone for treatment of croup in children. A randomized, double‐blind clinical trial was implemented on 174 patients with croup, aged from 6 months to 6 years, and admitted to the Amir Kabir Pediatric Hospital (Arak, Iran). After randomized allocation, patients were administered dexamethasone, and then, they received either saline or L‐epinephrine. Westley croup scores, heart rate, respiratory rate, and blood pressure were recorded every half an hour for a total of 120 min. There was a significant difference in mean of croup scores between two groups ( P < 0.009). In addition, a significant difference was seen on mean of heart rate between two groups ( P < 0.026). Our results showed a considerable difference in reduction of velocity of croup scores in patients who received nebulized L‐epinephrine compared to patients who received placebo.