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Angiotensin‐converting enzyme inhibition prevents myocardial infarction‐induced increase in renal cortical cGMP and cAMP phosphodiesterase activities
Author(s) -
Clauss François,
Charloux Anne,
Piquard François,
Doutreleau Stéphane,
Talha Samy,
Zoll Joffrey,
Lugnier Claire,
Geny Bernard
Publication year - 2015
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12124
Subject(s) - medicine , endocrinology , phosphodiesterase , atrial natriuretic peptide , cyclic guanosine monophosphate , myocardial infarction , renin–angiotensin system , natriuretic peptide , kidney , angiotensin ii , pde10a , chemistry , enzyme , receptor , heart failure , biochemistry , blood pressure , nitric oxide
We investigated whether myocardial infarction ( MI ) enhances renal phosphodiesterases ( PDE ) activities, investigating particularly the relative contribution of PDE 1‐5 isozymes in total PDE activity involved in both cGMP and cAMP pathways, and whether angiotensin‐converting enzyme inhibition ( ACE i) decreases such renal PDE hyperactivities. We also investigated whether ACE i might thereby improve atrial natriuretic peptide ( ANP ) efficiency. We studied renal cortical PDE 1‐5 isozyme activities in sham ( SH )‐operated, MI rats and in MI rats treated with perindopril ( ACE i) 1 month after coronary artery ligation. Circulating atrial natriuretic peptide ( ANP ), its second intracellular messenger cyclic guanosine monophosphate ( cGMP ) and cGMP / ANP ratio were also determined. Cortical cGMP ‐ PDE 2 (80.3 vs. 65.1 pmol/min/mg) and cGMP ‐ PDE 1 (50.7 vs. 30.1 pmol/min/mg), and cAMP ‐ PDE 2 (161 vs. 104.1 pmol/min/mg) and cAMP ‐ PDE 4 (307.5 vs. 197.2 pmol/min/mg) activities were higher in MI than in SH rats. Despite increased ANP plasma level, ANP efficiency tended to be decreased in MI compared to SH rats. Perindopril restored PDE activities and tended to improve ANP efficiency in MI rats. One month after coronary ligation, perindopril treatment of MI rats prevents the increase in renal cortical PDE activities. This may contribute to increase renal ANP efficiency in MI rats.