Premium
Pharmacology and mechanisms of action of new oral anticoagulants
Author(s) -
Salem JoeElie,
Sabouret Pierre,
FunckBrentano Christian,
Hulot JeanSebastien
Publication year - 2015
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1111/fcp.12091
Subject(s) - medicine , atrial fibrillation , clinical pharmacology , pharmacology , homogeneous , intensive care medicine , stroke (engine) , action (physics) , orally active , oral administration , mechanical engineering , physics , quantum mechanics , engineering , thermodynamics
The new oral anticoagulants are announced as an important therapeutic revolution, particularly after their approval by authorities for stroke prevention in atrial fibrillation. However, the pharmacology of these new drugs is not homogeneous. In this review, we summarize the main pharmacological characteristics of the new direct anti‐Xa and anti‐ II a agents.