Resveratrol attenuates bone cancer pain through the inhibition of spinal glial activation and CX 3 CR 1 upregulation

The present study examined the effects of intrathecal use of resveratrol on pain hypersensitivities, spinal glia activation, and CX 3 CR 1 expression in the model of bone cancer pain ( BCP ). The BCP model was established through intrathecally injecting W alker 256 mammary gland carcinoma cells to S prague‐ D awley rats. We found that spinal CX 3 CR 1 expression and glial activation aggravated after inoculation. Resveratrol (i.t.) attenuated bone cancer‐induced pain hypersensitivities, decreased CX 3 CR 1 expression and glial activation in the spine in a BCP model. Resveratrol (i.t.) also attenuated mechanical allodynia resulting from intrathecally injecting fractalkine in rats. Inhibition of spinal glial activation and CX 3 CR 1 upregulation may involve in resveratrol's analgesic effects. These findings demonstrated that resveratrol attenuated pain facilitation through inhibiting spinal glial activation and CX 3 CR 1 upregulation in a BCP model.