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Laminins and interaction partners in the architecture of the basement membrane at the dermal‐epidermal junction
Author(s) -
Aumailley Monique
Publication year - 2021
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14239
Subject(s) - basement membrane , perlecan , laminin , extracellular matrix , epidermis (zoology) , dermis , microbiology and biotechnology , dermoepidermal junction , chemistry , biology , anatomy , proteoglycan
Abstract The basement membrane at the dermal‐epidermal junction keeps the epidermis attached to the dermis. This anatomical barrier is made up of four categories of extracellular matrix proteins: collagen IV, laminin, nidogen and perlecan. These proteins are precisely arranged in a well‐defined architecture through specific interactions between the structural domains of the individual components. Some of the molecular constituents are provided by both fibroblasts and keratinocytes, while others are synthesized exclusively by fibroblasts or keratinocytes. It remains to be determined how the components from the fibroblasts are targeted to the dermal‐epidermal junction and correctly organized and integrated with the proteins from the adjacent keratinocytes to form the basement membrane.